منابع مشابه
Studies in Sensitization to Skin
1. Techniques for the preparation of skin antigen suitable for intramuscular injection in rabbits, and of skin antigens (autolysate) for serological experiments are described. 2. A method was evolved which produced a soluble skin antigen (autolysate) suitable for performing precipitin tests. 3. Injection of the rabbit skin antigen and of staphylococcus toxin in rabbits resulted in the formation...
متن کاملSkin Sensitization to Remiderm and Cross-sensitization to Hydroxyquinoline Compounds.
EDITSHAL and usually, as in the present case, constructional apraxia will be detected with or without ideational apraxia, alexia, or sensory agnosia. Interpretation of Gerstmann's syndrome as an easily demonstrated and memorable pointer to diffuse cerebral damage accords well with this case, where there is no reason to suspect a highly focal lesion. Gerstmann's syndrome does not seem to have be...
متن کاملSkin exposure promotes a Th2-dependent sensitization to peanut allergens.
Sensitization to foods often occurs in infancy, without a known prior oral exposure, suggesting that alternative exposure routes contribute to food allergy. Here, we tested the hypothesis that peanut proteins activate innate immune pathways in the skin that promote sensitization. We exposed mice to peanut protein extract on undamaged areas of skin and observed that repeated topical exposure to ...
متن کاملFragrances Categorized According to Relative Human Skin Sensitization Potency
BACKGROUND The development of non-animal alternatives for skin sensitization potency prediction is dependent upon the availability of a sufficient dataset whose human potency is well characterized. Previously, establishment of basic categorization criteria for 6 defined potency categories, allowed 131 substances to be allocated into them entirely on the basis of human information. OBJECTIVES ...
متن کاملEvaluation of dermal irritation and skin sensitization due to vitacoxib
The prediction of side-effects is a key issue in the REACH initiative on chemicals in the preclinical testing of drugs. The dermal irritation and skin sensitization toxicity potential of a new molecule, vitacoxib, were invested in rabbits and guinea pigs in compliance with the Organization for Economic Cooperation and Development guideline. To assess dermal irritation, rabbits were dermally att...
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ژورنال
عنوان ژورنال: BMJ
سال: 1948
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.4572.387